Healthcare Provider Information - ellura®
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Healthcare Providers

Help Your Patients Stay One Step Ahead of UTIs

ellura®, a natural non-antibiotic alternative for UTI management(7), delivers 36mg of soluble, bioactive PACs from 100% concentrated cranberry fruit juice extract(2,3). Trusted by healthcare professionals in the US for over 15 years.

ellura product illustration

ellura is Backed by Real Science and Designed for Results

Don’t settle for alternatives, choose the best for your patients’ urinary tract health(16,17).

Scientific backing illustration

A Clinically Effective Choice for rUTI Defense

ellura is not just a cranberry supplement, it’s the result of 20+ years of pioneering research, 22 Health Regulatory Agency approvals worldwide, and an unwavering commitment to provide the highest level of protection against rUTIs (2,13,15).

When it comes to science, precision, and quality, Pharmatoka sets the standard.

Why ellura is Clinically Effective

ellura is made of 100% concentrated cranberry fruit juice extract and consists of soluble A-type PACs ensuring maximum bioactivity and anti-adhesion activity (AAA) against UTI-causing bacteria(1,2,5), unlike most cranberry supplements, which contain insoluble PACs from pomace (skins, seeds, and pulp), that show little or no bioactivity(15).

Only A-Type PACs lead to bacterial anti-adhesion activity and the soluble PACs are only found in the juice of the cranberry fruit, not in any other part of the cranberry(1,2). Pharmatoka’s proprietary cutting-edge extraction process preserves the soluble A-type PACs and their bioactivity, ensuring that they remain fully effective to prevent bacterial adhesion(2,13).

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Why ellura is Clinically Effective

ellura delivers 36 mg of bioactive soluble PACs per capsule—an amount clinically proven to prevent the adhesion of uropathogenic E. coli in the urinary tract (1,2,3,5,13). In contrast, most other cranberry supplements either lack PAC standardization or contain insufficient quantities to be effective(15).

ellura inhibits the adhesion of both P-fimbriated (P-type) and Type 1-fimbriated E. coli, the primary culprits behind UTIs, offering broad-spectrum protection against recurrent urinary tract infections (5,13).

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Bacteria animation

How ellura Works

Only Soluble A-type PACs and their metabolites inhibit uropathogenic E. coli bacteria from adhering to the epithelial cells lining the urinary tract(1,2,5), the critical first step in infection. This anti-adhesion effect begins within hours, peaks around 6 hours, and can last up to 24 hours(3).

Step 1. Bacteria Enter and Attach

Harmful E. coli from the gut can travel to the urinary tract, leading to UTIs.

Step 2. ellura Blocks

Clinically proven soluble PACs in ellura prevent bacteria from sticking to the urinary tract walls.

Step 3. Bacteria Are Flushed Out

Without attachment, bacteria are naturally eliminated through urine.

Helping Against Antibiotic Resistance

The rise of antimicrobial resistance, particularly in UTIs, has led to more research on non-antibiotic options for the prevention of rUTIs(7). The use of bioactive potent cranberry products is recommended in the management of rUTIs in the 2022 AUA/CUA/SUFU Guidelines(4).

We select the finest cranberry fruit, the key to unlocking our high-quality extract Gikacran with exceptional bioactivity and potency(2,5). Backed by 20 years of cutting-edge research, our proprietary extract is crafted from the best cultivars across premium growing regions in the USA and Chile. We meticulously optimize variety, extraction yield, and proanthocyanidin (PAC) content to drive powerful Anti-Adhesion Activity. Sourced with precision and formulated with expertise, our Gikacran extract delivers unmatched quality and consistency(16,17).

Medical Grade FormulationExpand

In 2016, Pharmatoka achieved a major milestone in obtaining its first Marketing Authorization for ellura as a Traditional Herbal Medicinal Product from the UK’s MHRA (Medicines and Healthcare Products Regulatory Agency).

Currently, Pharmatoka holds 22 Marketing Authorizations for ellura worldwide, further solidifying its reputation for excellence and innovation. Trusted by healthcare professionals and patients alike, ellura stands as a scientifically proven product backed by Pharmatoka’s commitment to quality and efficacy. Produced in Switzerland by a pharma GMP-certified manufacturer, ellura guarantees the highest quality, potency, and purity in every capsule.

In the US, ellura is sold as a medical-grade dietary supplement, recommended by leading urologists and trusted by thousands of patients for exceptional urinary tract support.

Feel the ellura difference

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American Herbal Pharmacopoeia (AHP) MonographExpand

In 2016, at Pharmatoka’s initiative (2012), the AHP published a 96-page monograph on cranberry, written by leading experts in cranberry research. These studies have highlighted the importance of standardized proanthocyanidins (PACs) in preventing bacterial adhesion. ellura stands out as a leading U.S. supplement, delivering 36 mg of PAC per capsule and the highest bioactivity ever measured, proven to reduce the adhesion of E. coli to the urinary tract wall epithelium, effectively disrupting UTI development(1,2,5).

Click here to read the UTI section of the monograph. To receive a copy of the full monograph, please contact us.(16)
American Botanical Council (ABC)’s Varro E. Tyler AwardExpand

In 2018, the American Botanical Council (ABC) honored Pharmatoka with the prestigious Varro E. Tyler award, recognizing its investment in Phytomedicinal research. Acknowledging Pharmatoka’s leadership in cranberry science, ABC states that “Pharmatoka is respected for its research leadership on cranberry, and its research has helped to set the therapeutic standard for cranberry extracts”.*

This award reaffirms Pharmatoka’s commitment to innovation, quality, and evidence-based natural health solutions, reinforcing its position as a global leader in cranberry science.

*Citation Issue 118-2018-www.herbalgram.co 

United States Pharmacopoeia (USP) MonographExpand

USP is a scientific nonprofit organization that sets public standards for identity, strength, quality, and purity of medicines and dietary supplements(17).

In December 2023, after more than 10 years of research and investigation and at the initiative of Pharmatoka, the USP published two Monographs on:

  • Cranberry Fruit Juice Dry Extract (1)
  • Cranberry Fruit Juice Dry Extract Capsules (2)

Pharmatoka’s Gikacran extract and ellura capsules were the reference products in both Monographs, reaffirming their scientific excellence and quality.

ellura quality illustration

Scientific Studies

Learn more about some of ellura’s scientific and clinical studies.

ellura vs. D-Mannose, Howell AB, 2024

Side-by-side comparison shows ellura effectively prevents adhesion of both P-type and Type 1 pili of E. coli, unlike D-Mannose which targets only Type 1 pili. Read Study

Asymptomatic bacteriuria after cystoplasty, Botto H, 2010

Effectiveness of cranberry (Vaccinium macrocarpon), Ginkacran®, in reducing asymptomatic bacteriuria in patients following ileal enterocystoplasty. Read Study

Only soluble, A-Type PACs extracted from pure cranberry juice led to Anti-Adhesion Activity, Howell, 2021

In-vitro and ex-vivo P-fimbriated E. coli bacterial Anti-Adhesion Activity (AAA) (from different parts of the berry?) Read Study

Catheter-associated urinary tract infections, Thomas D, 2017

The cranberry supplement reduced symptomatic Catheter-associated UTIs, antibiotic resistance, and major causative organisms in this cohort. Read Study

Variability of commercial cranberry products for the prevention of uropathogenic bacterial adhesion, Chughtai B, 2016

There is a high variability of active compound among cranberry supplements. Most do not contain enough PACs for rUTI prevention. Read Study

Cranberry syrup shows non-inferiority to antibiotic for recurrent UTIs, Uberos J, 2012

Cranberry syrup vs trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial. Read Study

Optimal dose of ellura is identified for UTI prevention, Howell AB, 2010

Dosage effect on uropathogenic E. coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study.
36 mg PACs per day is the minimum effective dose. 72 mg/day provides more protection, but the difference in antiadhesion activity is negligible. Read Study

Additional studies are available upon email request.

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FAQs

About ellura

What is ellura?

ellura is a powerful, medical-grade supplement clinically proven to keep your urinary tract clean. By keeping bacteria from sticking to your urinary tract and flushing them out naturally, ellura helps you stay UTI-free(1)(2)(5).

Why does ellura have a new design?

ellura still the same high-quality, medical-grade supplement you know and trust—only the packaging has changed. Now delivered directly from Pharmatoka, its original creators, ellura continues to provide the powerful formula you rely on.

What are the ingredients inellura?

Each capsule delivers a potent 36 mg of Proanthocyanidins (PACs) from 206 mg of concentrated cranberry juice extract (Gikacran), the key ingredient clinically proven to help prevent UTIs. Encapsulated in a 100% plant-based formula, ellura ensures optimal absorption and effectiveness(2,3,13).

Inactive ingredients: Mannitol, Magnesium Stearate, silicon dioxide, and the vegetable shell(Hydroxypropylmethylcellulose) are used to prevent ingredients from sticking together during the manufacturing process to increase product stability and keep the active ingredient (PACs) more bioavailable.

Can I open the ellura capsules if I have trouble swallowing them?

Yes, you can open the ellura capsule, but we recommend mixing the powder with soft food (ex. yogurt, pudding, applesauce) or sweet beverage (i.e. juice) rather than taking it directly, as it has a naturally bitter, astringent taste.

How ellura Works

How does ellura work?

ellura works by harnessing the power of 36 mg of potent Proanthocyanidins (PACs) from 100% pure cranberry juice(1,3,8). These soluble and bioactive PACs bind to bacteria, preventing them from sticking to the bladder wall(2). Without the ability to adhere, bacteria are naturally flushed out, helping to keep you UTI-free.

What are proanthocyanidins (PACs)?

Proanthocyanidins (PACs) are natural compounds found in cranberries and some other fruits. Research shows that the unique A-type PACs in cranberries help support urinary tract health*(1,2). ellura uses a unique/exclusive extraction process to ensure each capsule contains a precise, bioactive, and medical-grade dose of PACs for maximum effectiveness.

Why is ellura better than other cranberry supplements?

Not all cranberry supplements are created equal. Many lack the necessary 36 mg of bioactive PACs to be effective(15). ellura stands apart because it is made from pure cranberry juice concentrate, ensuring a potent, medical-grade dose of soluble PACs—the only type proven to prevent UTI-causing bacteria from sticking to the bladder(1,5). Standardized using the scientifically validated DMAC/A2 method and backed by 25 years of research and 22 herbal medicinal approvals worldwide, ellura delivers trusted, clinically proven UTI protection(7) in just one capsule a day.

How to Take ellura

Who can benefit from taking ellura?

ellura is ideal for anyone prone to frequent UTIs, especially women. Some common UTI triggers are sex, birth control, menopause, diabetes, mobility issues, or catheter use(6,7,9,11,14). Men can also get UTIs, but since they may be linked to other health conditions, they should consult with their health care provider before taking ellura.

Do I need a prescription to take ellura?

Lucky for you, no prescription is required for you to obtain ellura. Although ellura is made from medical-grade 36 mg of PAC (proanthocyanidins) that is backed by scientific research and trusted by healthcare providers. ellura is a dietary supplement in the USA and does not require a prescription.

How often should I take ellura?

To maintain a clean urinary tract, take 1 capsule daily with water about the same time each day. ellura can be used occasionally or repeatedly, as needed, or as recommended by your healthcare provider. For specific triggers like sexual activity, travel, stress, dehydration, or early signs of discomfort, you can take 2 capsules per day as needed, then return to your regular dose of 1 capsule daily(3,8).

While ellura does not treat or cure a UTI, it helps reduce the risk of future infections. If you have an active UTI, take ellura daily alongside your prescribed antibiotics to help flush out bacteria.

Can I take ellura with a prescribed antibiotic?

Yes, you can take ellura alongside your prescribed antibiotic for extra support in flushing out UTI-causing bacteria. However, ellura is not a substitute for antibiotics, which are necessary to treat an active infection(4). Once the infection clears, continue taking ellura daily to help maintain a healthy urinary tract(4). Keep in mind that our goal with ellura is to help to protect you from future infections. Because long-term antibiotic use for prevention may lead to resistance and unwanted side effects(4), you should work with your physician to find the best prevention strategy for you and the specific bacteria that plagues you.

Can ellura replace an antibiotic?

No, ellura cannot replace an antibiotic. If you have a confirmed UTI, you will likely need an antibiotic to treat it. However, you can take ellura alongside your antibiotic to support flushing out UTI-causing bacteria. Once the infection clears, continue taking ellura daily to help maintain a healthy urinary tract. Keep in mind that long-term antibiotic use can lead to resistance and unwanted side effects, so consult your healthcare provider for the best prevention strategy(4).

Quality

Is ellura suitable for vegans?

Yes, ellura is encapsulated in 100% plant based formula!

How is ellura tested for quality?

ellura is rigorously tested for quality at every stage. Manufactured in Switzerland under Good Manufacturing Practices (GMP), it ensures each batch meets strict standards for purity and potency. Our Gikacran® extract complies with USP standards and is free from harmful contaminants, ensuring the highest quality and safety(14,16,18).

Safety Information

Is ellura acidic?

ellura has a similar acidity level (ph value) to a cup of coffee(5), soda(4-5), or tomatoes(4-5).

For Comparison: water has a neutral pH of 7; Cranberry juice is much more acidic, with a pH of 2.7. ellura falls about halfway between the two, with a pH of 4.44. This means ellura is mildly acidic but significantly less so than cranberry juice.

Although we compare ellura to a cup of coffee, rest assured that ellura does not contain any caffeine.

Can I be allergic to ellura?

ellura is well-tolerated, but if you have a red fruit allergy, it's best to check with your healthcare provider before taking it. ellura's active ingredient,(PACs), are extracted from concentrated cranberry juice extract, a red fruit.

Does ellura contain GMOs, artificial ingredients, or common allergens like gluten, dairy, or soy?

ellura is well-tolerated, but if you have a red fruit allergy, it's best to check with your healthcare provider before taking it. ellura's active ingredient,(PACs), are extracted from concentrated cranberry juice extract, a red fruit.

Is ellura suitable for children?

Yes, ellura is safe for children and has been used for years with no reported side effects. Children under 50lbs can take half a capsule daily, while those 50lbs or more can take one full capsule daily. If swallowing is difficult, the capsule can be opened and mixed into a sweet beverage or soft food(7).

Is ellura safe for pregnant and nursing women?

There are no studies on ellura in pregnant or nursing women. While cranberry is generally considered safe and natural, we recommend consulting your healthcare provider before use.

Can I take ellura if I have diabetes?

Yes. When taken at the recommended dose, ellura is unlikely to affect blood sugar levels, including individuals who manage their blood sugar daily.

Can I take ellura if I'm on blood thinners?

A potential interaction cannot be ruled out. If you are taking blood thinners (anticoagulant medication), consult your healthcare provider before using ellura.

Are there any side effects from taking ellura?

ellura is generally well-tolerated and not expected to cause side effects. However, if you experience any, consult your healthcare provider. For further assistance, you can contact us at help@pharmatoka.com or call (888) 481-6590.

Can I take ellura with other supplements or medications?

As with starting any new medication or supplements, it's important to consult your healthcare provider.

Can ellura cause kidney stones or worsen existing ones?

ellura contains low levels of oxalates, only 0.108 mg per capsule, which is much lower than in pure cranberry juice or the whole fruit. While long-term studies provide conflicting data on cranberry and kidney stones, the low oxalate content in ellura makes it unlikely to cause or worsen kidney stones. If you have a history of kidney stones or severe kidney disease, it's best to consult your healthcare provider before taking ellura.

Does ellura help with interstitial cystitis (IC)?

While an IC "flare" and UTI symptoms can often feel the same, ellura is not a treatment for interstitial cystitis (IC). However if UTI's tend to cause your IC "flare ups" then ellura may help. If acidity is a concern, ellura has an ph of 4.4, you can take it with an acid reducer. Always consult your healthcare provider for proper IC management and treatment.

REFERENCES:

  1. Howell, A. B., Vorsa, N., Der Marderosian, A., & Foo, L. Y. (1998). Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. The New England journal of medicine, 339(15), 1085–1086. https://doi.org/10.1056/NEJM199810083391516
  2. Howell AB, Dreyfus JF, Chughtai B. Differences in Urinary Bacterial Anti-Adhesion Activity after Intake of Cranberry Dietary Supplements with Soluble versus Insoluble Proanthocyanidins. J Diet Suppl.2022;19(5):621-639.
  3. Howell et al. , Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study.BMC Infectious Diseases 2010, 10:94
  4. Anger, J. T., Bixler, B. R., Holmes, R. S., Lee, U. J., Santiago-Lastra, Y., & Selph, S. S. Updates to Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. The Journal of Urology. 2022
  5. S. Bosley, Christian G. Krueger, A. Birmingham, AB. Howell, JD. Reed. Improved in vitro Hemagglutination Assays Utilizing P-Type and Type 1 Uropathogenic Escherichia coli to Evaluate Bacterial Anti-Adhesion Activity of Cranberry Products, Journal of Dietary Supplements 2024; 21(3): 327-343
  6. Storme O, Tiran Saucedo J, Garcia-Mora A, Dehesa-Davila M, Naber KG. Risk factors and predisposing conditions for urinary tract infection. The Adv Urol 2019;11:1756287218814382.
  7. Uberos J. et al. Cranberry syrup vs Trimethoprim in the prophylaxis of recurrent urinary tract infections among children: a controlled trial Open Access. Journal of CLinical Trials 2012:4: 31-38
  8. Lavigne JP, Bourg G, Combescure C, et al. (2008) In vitro and in vivo evidence of dose-dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules. Clin Microbiol Infect 14(4): 350–5.
  9. Botto H. Neuzillet Y. (2010) Effectiveness of a cranberry (Vaccinium macrocarpon) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty. Scand J Urol Nephrol 2010 Apr; 44(3):165-8.
  10. Muthani-Mehta et al. (2012) Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. Letters to the editor. June 2012 – Journal of the American Geriatrics Society. Vol 60, n°6.
  11. Thomas D et al. (2017) Can Urol Assoc J. Does cranberry have a role in catheter-associated urinary tract infections? Can Urol Assoc J 2017;11(11):E421-4. Lavigne JP, G.Bourg, H.Botto, A. Sotto. (2007) Cranberry (Vaccinium macrocarpon) and urinary tract infections : study model and review of literature. Pathologie Biologie 2007.07.005.
  12. Howell AB, Dreyfus JF, Bosley S, Krueger CG, Birmingham A, Reed JD, Chughtai B. Differences in P-Type and Type 1 Uropathogenic Escherichia coli Urinary Anti-Adhesion Activity of Cranberry Fruit Juice Dry Extract Product and D-Mannose Dietary Supplement. J Diet Suppl. 2024 May 28:1-27.
  13. Sintara M, Li L, Cunningham DG, Prior RL, Wu X, Chang T. Single-Laboratory Validation for Determination of Total Soluble Proanthocyanidins in Cranberry Using 4-Dimethylaminocinnamaldehyde. J AOAC Int. 2018 May 1;101(3):805-809.
  14. Chughtai B, Thomas D, Howell A. Variability of commercial cranberry dietary supplements for the prevention of uropathogenic bacterial adhesion. American Journal of Obstetrics & Gynecology. 2016;215(1):122-123.
  15. AHP - Upton, R., & Brendler, T. (2016). Cranberry Fruit Vaccinium macrocarpon Aiton- Standards of Analysis, Quality Control, and Therapeutics. American Herbal Pharmacopoeia (AHP) and Therapeutic Compendium. American Herbal Pharmacopoeia® • Cranberry Fruit • 2016
  16. USP - Cranberry Fruit Juice Dry Extract. (2023). United States Pharacopeia-National Formulary (USP-NF).
ReferencesExpand
  1. Howell, A. B., Vorsa, N., Der Marderosian, A., & Foo, L. Y. (1998). Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. The New England Journal of Medicine, 339(15), 1085–1086. https://doi.org/10.1056/NEJM199810083391516
  2. Howell, A. B., Dreyfus, J. F., & Chughtai, B. (2022). Differences in urinary bacterial anti-adhesion activity after intake of cranberry dietary supplements with soluble versus insoluble proanthocyanidins. Journal of Dietary Supplements, 19(5), 621–639.
  3. Howell, A. B., et al. (2010). Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: A multicentric randomized double blind study. BMC Infectious Diseases, 10, 94.
  4. Anger, J. T., Bixler, B. R., Holmes, R. S., Lee, U. J., Santiago-Lastra, Y., & Selph, S. S. (2022). Updates to recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU Guideline. The Journal of Urology.
  5. Bosley, S., Krueger, C. G., Birmingham, A., Howell, A. B., & Reed, J. D. (2024). Improved in vitro hemagglutination assays utilizing P-type and type 1 uropathogenic Escherichia coli to evaluate bacterial anti-adhesion activity of cranberry products. Journal of Dietary Supplements, 21(3), 327–343.
  6. Storme, O., Tirán Saucedo, J., Garcia-Mora, A., Dehesa-Dávila, M., & Naber, K. G. (2019). Risk factors and predisposing conditions for urinary tract infection. Therapeutic Advances in Urology, 11, 1756287218814382.
  7. Uberos, J., et al. (2012). Cranberry syrup vs trimethoprim in the prophylaxis of recurrent urinary tract infections among children: A controlled trial. Open Access Journal of Clinical Trials, 4, 31–38.
  8. Lavigne, J. P., Bourg, G., Combescure, C., et al. (2008). In vitro and in vivo evidence of dose-dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules. Clinical Microbiology and Infection, 14(4), 350–355.
  9. Botto, H., & Neuzillet, Y. (2010). Effectiveness of a cranberry (Vaccinium macrocarpon) preparation in reducing asymptomatic bacteriuria in patients with an ileal enterocystoplasty. Scandinavian Journal of Urology and Nephrology, 44(3), 165–168.
  10. Juthani-Mehta, M., et al. (2012). Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. Journal of the American Geriatrics Society, 60(6).
  11. Thomas, D., et al. (2017). Does cranberry have a role in catheter-associated urinary tract infections? Canadian Urological Association Journal, 11(11), E421–E424.
  12. Lavigne, J. P., Bourg, G., Botto, H., & Sotto, A. (2007). Cranberry (Vaccinium macrocarpon) and urinary tract infections: Study model and review of literature. Pathologie Biologie, 2007.07.005.
  13. Howell, A. B., Dreyfus, J. F., Bosley, S., Krueger, C. G., Birmingham, A., Reed, J. D., & Chughtai, B. (2024). Differences in P-type and type 1 uropathogenic Escherichia coli urinary anti-adhesion activity of cranberry fruit juice dry extract product and D-mannose dietary supplement. Journal of Dietary Supplements, 1–27.
  14. Sintara, M., Li, L., Cunningham, D. G., Prior, R. L., Wu, X., & Chang, T. (2018). Single-laboratory validation for determination of total soluble proanthocyanidins in cranberry using 4-dimethylaminocinnamaldehyde. Journal of AOAC International, 101(3), 805–809.
  15. Chughtai, B., Thomas, D., & Howell, A. (2016). Variability of commercial cranberry dietary supplements for the prevention of uropathogenic bacterial adhesion. American Journal of Obstetrics & Gynecology, 215(1), 122–123.
  16. Upton, R., & Brendler, T. (2016). Cranberry fruit Vaccinium macrocarpon Aiton - Standards of analysis, quality control, and therapeutics. American Herbal Pharmacopoeia and Therapeutic Compendium.
  17. Cranberry Fruit Juice Dry Extract. (2023). United States Pharmacopeia-National Formulary (USP-NF).